The trial will last for about five years for all recipients, which includes at least 21 to 33 study visits.
Some of these visits may coincide with routine clinic visits and care. Some visits may be able to take place at home.
A treatment that stimulates the stem cells in your bone marrow to enter your blood stream. You will receive filgrastim, a medicine used to mobilize your stem cells, as a subcutaneous injection (under the skin).
You may also receive corticosteroids to help prevent a scleroderma flare from the filgrastim.
A procedure that collects your stem and immune cells after mobilization using an intravenous (IV) catheter. Apheresis takes about four to six hours, but you may have to come to the hospital the day before to have the apheresis catheter inserted.
Your cells are collected in case your body doesn’t accept your donor’s cells and you need to be given back your own cells.
A process of administering conditioning medicines (through a vein in your arm) and a single low dose of radiation to prepare you for the stem cell transplant. Conditioning is used to suppress your immune system, make room for new stem cells, and allow your body to accept your donor’s cells which will remain in your bone marrow and blood.
Conditioning medicines will be administered for three days. Then, you will receive one low dose of radiation (lasting about 30 minutes) two days before the stem cell transplant.
The study team will discuss all procedures with you and answer any questions you may have.
Download this e-Guide to help inform conversations with your healthcare provider.